Using magic mushrooms: safe, conscious and responsible

Psilocybe serbica is a potent psilocybin-containing mushroom found in Europe, known for its strong effects, unique characteristics, and specific habitats. In this blog, you'll learn exactly how to identify, use, and even grow it yourself.

What are magic mushrooms, and how do they affect your brain?

Magic mushrooms, or psilocybin-containing mushrooms, contain the psychoactive compound psilocybin, which is converted into psilocin in your body. This substance interacts with serotonin receptors in the brain, potentially leading to intense changes in perception, emotions, and thought patterns.

Scientific interest in psilocybin is growing, particularly as a potential treatment for mental health conditions such as depression and addiction—when used under professional supervision. Studies like those by Carhart-Harris et al. (2016) have shown that psilocybin can have profound therapeutic effects under controlled conditions.

Outside clinical settings, many people choose to use magic mushrooms for self-reflection, spiritual growth, or simply out of curiosity. Good preparation is crucial in such cases.

Why do people choose to use magic mushrooms?

Motivations for using magic mushrooms vary widely. Some seek deep self-reflection or inner healing, while others hope to find relief from depression or anxiety, often with the guidance of a therapist. There are also users who take mushrooms to enhance sensory perception or to pursue spiritual or mystical experiences. Whatever the reason, proper preparation and the right environment are key to a safe and meaningful experience.

Note: While many users report positive effects, preparation and setting are essential for a safe experience.

Set and Setting: The foundation of a safe trip

Two main factors influence the course of a mushroom trip:

• Set (mindset): Your mental and emotional state. Feeling stressed, anxious, or down? Postpone your trip.
• Setting (environment): Choose a safe, familiar, and calm place without external obligations or distractions.

Tip: Do not use mushrooms if you're mentally unstable, under the influence of other substances, or feel unsafe in your surroundings.

Dosage: How much is safe?

The right dosage depends on your experience, body weight, and the type of mushrooms or truffles. The table below offers general guidelines:

Always start with a low dose if you're a first-time user.

What to expect during a mushroom trip?

A mushroom trip typically lasts between four and six hours. The most intense phase usually occurs between the second and fourth hour. Users often report visual distortions, colorful patterns, and an enhanced sense of emotion or insight. The sense of time may completely fade, and some feel a deep connection with nature or the universe. Despite these often positive experiences, moments of confusion, fear, or loss of control may also occur. This is why having a sitter is highly recommended, especially for beginners.

Common experiences include:

• Visual distortions and colorful patterns
• Intense emotions or insights
• Loss of time perception
• Sense of connection with nature or the universe
  
  

While often positive, confusion, anxiety, or loss of control can also occur. Guidance is essential.

Safety tips for using magic mushrooms

If you're planning to use mushrooms, preparation is key. Ideally, use them in the company of a sober and experienced trip sitter, avoid combining them with alcohol or other substances, and choose a calm, familiar environment. Eat lightly beforehand to reduce nausea, and make sure to purchase your mushrooms from a reputable smartshop. Most importantly: trust your instincts and postpone use if you feel unsure.

Warning: Do not use mushrooms if you have a mental health condition like psychosis or bipolar disorder. When in doubt, consult a doctor.

Are mushrooms legal in the Netherlands?

Dried mushrooms are prohibited. Fresh truffles, however, are legal and also contain psilocybin. They are sold openly in smartshops and tend to be slightly milder in effect.

Use mushrooms with awareness and respect

Mushrooms can offer insight, healing, and connection—but only when used with respect, knowledge, and preparation. Educate yourself thoroughly, seek guidance, and listen to your inner voice.

Sources & Further Information

For in-depth and scientific information referenced in this blog, see:

• Johns Hopkins – Psychedelic Research
• MAPS – Psilocybin Studies
• Trimbos – Information on Mushrooms
• Government of the Netherlands – Drugs and Legislation
  
  

Frequently Asked Questions About Magic Mushrooms

How long do magic mushrooms stay in your system?

Psilocin (the active compound) usually leaves your body within 1 to 3 days. It's detectable in blood for a short time, and in urine for up to 48 hours.

Can you get addicted to magic mushrooms?

Physical addiction doesn’t occur. Psychological dependence is rare, as tolerance builds up quickly.

Can you combine magic mushrooms with antidepressants?

Not without consulting a doctor. Antidepressants can reduce, intensify, or unpredictably alter the effects. There's also a risk of serotonin syndrome.

Disclaimer

The information on this page is intended for educational and informational purposes only. The use of psilocybin-containing mushrooms is regulated or prohibited in many countries. Always consult local laws before considering the use of such substances. Psilocybin can have psychological and physical effects and is not suitable for minors, pregnant women, or people with mental or physical health issues. Use is entirely at your own risk. When in doubt, always consult a doctor or medical professional. This text is not a substitute for professional medical advice.

Written by: Dr. Paddo Content Team